Neurological Disorders
Neuropathies tend to be associated with late-onset celiac disease. Dementia and ataxia appear to be more common. A recent study of children with neuropathies revealed no increase of CD in early-onset neuropathies. Although many studies link CD to various neuropathies such as migraine, encephalopathy, chorea, brain stem dysfunction, myelopathy, mononeuritis multiplex, Guillain-Barre-like syndrome, and antiganglioside-positive neuropathy with antibodies, strong associations remain largely unconfirmed in epidemiologic studies. A recent study looking for changes in the physiology of the brain found regional cerebral hypoperfusion in 73% of untreated CD. The calcification of channels at the surface of the brain appears to be a leading phenomenon associated with migraine, visual, auditory, schizophrenia, epilepsy, dementia. The problem is that while these are found increased in GSE, the cause of these calcifications is unclear and this may extend beyond GSE to other immunological or allergic phenomena. A 2007 study in Sweden of 14,000 GSE patients revealed no association of CD with multiple sclerosis, Parkinson's disease, Alzheimer's disease, hereditary ataxia, ataxia(the symptom), Huntington's disease, myasthenia gravis, or spinal muscular atrophy, but prior polyneuropathy was associated with subsequent CD. However, a 2009 study of myasthenics revealed that 1 in 23 had high levels of anti-transglutaminase.
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