Disorders and Conditions
Numerous reports have been published indicating that the glutamate/GABA-glutamine cycle is affected in a variety of neurological disorders and conditions. Biopsies of sclerotic hippocampus tissue from human subjects suffering from epilepsy have shown decreased glutamate-glutamine cycling. Another pathology in which the glutamate/GABA-glutamine cycle might be compromised is Alzheimer's disease, NMR spectroscopy showed decreased glutamate neurotransmission activity and TCA cycling rate in patients suffering from Alzheimer's disease. Hyperammonemia in the brain, typically occurring as a secondary complication of primary liver disease and known as hepatic encephalopathy, is a condition that has an impact on glutamate/GABA-glutamine cycling in the brain.
Read more about this topic: Glutamate-glutamine Cycle
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