Clinical Significance
A missense mutation in the GCGR gene is associated with diabetes mellitus type 2.
Inactivating mutation of glucagon receptor in humans causes resistance to glucagon and is associated with pancreatic alpha cell hyperplasia, nesidioblastosis, hyperglucagonemia, and pancreatic neuroendocrine tumors.
Read more about this topic: Glucagon Receptor
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)