Clinical Significance
A missense mutation in the GCGR gene is associated with diabetes mellitus type 2.
Inactivating mutation of glucagon receptor in humans causes resistance to glucagon and is associated with pancreatic alpha cell hyperplasia, nesidioblastosis, hyperglucagonemia, and pancreatic neuroendocrine tumors.
Read more about this topic: Glucagon Receptor
Famous quotes containing the word significance:
“To grasp the full significance of life is the actor’s duty, to interpret it is his problem, and to express it his dedication.”
—Marlon Brando (b. 1924)