Gli3

GLI3

Gli3 is a known transcriptional repressor but may also have a positive transcriptional function. Gli3 represses dHand and Gremlin, which are involved in developing digits. There is evidence that Shh-controlled processing (e.g., cleavage) regulates transcriptional activity of Gli3 similarly to that of CI. Gli3 mutant mice have many abnormalities including CNS and lung defects and limb polydactyly.