Giuffrè or Giuffre may refer to:
- Aldo Giuffrè (born 1924), Italian film actor and comedian who appeared in over 90 films between 1948 and 2001
- Antonino Giuffrè (born 1945), Italian mafioso from Caccamo in the Province of Palermo, Sicily
- Carlo Giuffrè (born 1928), Italian film actor
- Jimmy Giuffre (1921–2008), American jazz composer, arranger and saxophone and clarinet player
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