GHB may refer to:
- gamma-Hydroxybutyric acid, a neuroprotective and depressant drug that is illegal in a number of countries
- glycated hemoglobin, a form of hemoglobin created during its exposure to high plasma levels of glucose
- Gabo d'Hirutho d'Bethnahrin, a militant Assyrian party labeled by the Turkish Government as a terrorist group
- Great Highland Bagpipe, a variety of bagpipe
- Gro Harlem Brundtland, former Prime Minister of Norway
- George H. W. Bush (born 1924), 41st President of the United States