George Klein may refer to:
- George Klein (inventor) (1904–1992), Canadian inventor
- George Klein (comics) (died 1969), American comic book artist
- George Klein (biologist) (born Klein György, 1925), Hungarian-Swedish biologist and writer
- George Klein (disc jockey) (born 1935), disc jockey and television host
- George S. Klein (1917–1971), American psychologist and psychoanalyst
- Adam Klein (swimmer) (George Klein IV, born 1988), American swimmer
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