Studies
IPASS (IRESSA Pan-Asia Study) was a randomized, large-scale, double-blinded study which compared gefitinib vs. carboplatin/ paclitaxel as a first line treatment in NSCLC. IPASS studied 1,217 patients with confirmed adenocarnicoma histology which were former or never smokers. A pre-planned sub-group analyses showed that progression-free survival (PFS) was significantly longer for IRESSA than chemotherapy in patients with EGFR mutation positive tumours (HR 0.48, 95 per cent CI 0.36 to 0.64, p less than 0.0001), and significantly longer for chemotherapy than IRESSA in patients with EGFR mutation negative tumours (HR 2.85, 95 per cent CI 2.05 to 3.98, p less than 0.0001). This, in 2009, was the first time a targeted monotherapy has demonstrated significantly longer PFS than doublet chemotherapy.
Read more about this topic: Gefitinib
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—Adrienne Rich (b. 1929)