GBS may refer to:
In medicine:
- Gastric bypass surgery, a class of medical procedures used to treat morbid obesity
- Group B streptococcus, a type of bacteria which causes a Group B streptococcal infection
- Guillain–Barré syndrome, an autoimmune disease affecting the peripheral nervous system
- Glasgow-Blatchford bleeding score, a screening tool for patients with acute upper gastrointestinal bleeding
- Gay bowel syndrome, an obsolete term that was sometimes used to refer to conditions supposedly more frequent in gay men
In education:
- Goizueta Business School, a highly ranked business school of Emory University in Atlanta, Georgia, United States
- God's Bible School and College, a Christian college in Cincinnati, Ohio, United States
- Gandaki Boarding School, formerly called Nepal Adarsha Vidyashram, a boarding school in Nepal
- Galgotias Business School, a management school in Greater Noida, India
- Glenbrook South High School, a high school in Glenview, Illinois, United States
- Gyeonggibuk Science High School, a science high school in Uijeongbu, Republic of Korea
- Goethe Business School, a graduate business school in Frankfurt am Main, Germany
In technology:
- Gravity-based structure, a support structure technique often used in building offshore oil platforms
- Global Broadcast Service, a United States Military communications network
- Game Boy Sound System, the audio playback technology used in the Nintendo Game Boy
- GNU build system, also known as Autotools, a suite of GNU project programming tools
- GBs, plural of gigabyte
- Gbs, short for gigabits per second, a data rate unit
- Grundy Business Systems, an English microcomputer company of the 1980s
- Global Business Services, a division of IBM Global Services
Other:
- The Gay Byrne Show, an Irish radio show (1974–1998)
- George Bernard Shaw (1856–1950), an Irish playwright
- Genotyping By Sequencing, a method of SNP genotyping
- Gifu Broadcasting System, a television and radio station in Gifu Prefecture, Japan
- Gold Bauhinia Star, the second highest rank in the Hong Kong honours system
- Golden Bauhinia Square, an open square in North Wan Chai, Hong Kong.
- Gram Bharati Samiti, or Society for Rural Development, a non-governmental organization in the Jaipur district of Rajasthan
- Große Berliner Straßenbahn, a former name of the Berlin Straßenbahn
- Great Big Sea, a Canadian folk-rock band
- Gürbetal-Bern-Schwarzenburg-Bahn, a former Swiss railway, now part of the Bern-Lötschberg-Simplon railway
- Gugun Blues Shelter, Indonesian music group
- Guillermo Barros Schelotto, an Argentine soccer player
- The IOC country code for Guinea-Bissau