GATA1

GATA1

Identifiers Symbols GATA1; ERYF1; GATA-1; GF-1; GF1; NFE1; XLANP; XLTDA; XLTT External IDs OMIM: 305371 MGI: 95661 HomoloGene: 1549 GeneCards: GATA1 Gene

Gene Ontology
Molecular function	• transcription regulatory region sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • RNA polymerase II transcription factor binding • enhancer sequence-specific DNA binding • p53 binding • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • DNA binding, bending • sequence-specific DNA binding • metal ion binding • C2H2 zinc finger domain binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex • nucleolus • transcriptional repressor complex • nuclear membrane
Biological process	• in utero embryonic development • transcription from RNA polymerase II promoter • cell-cell signaling • blood coagulation • negative regulation of cell proliferation • male gonad development • regulation of glycoprotein biosynthetic process • regulation of definitive erythrocyte differentiation • erythrocyte differentiation • megakaryocyte differentiation • platelet formation • basophil differentiation • eosinophil differentiation • negative regulation of bone mineralization • positive regulation of osteoblast proliferation • embryonic hemopoiesis • eosinophil fate commitment • negative regulation of apoptotic process • positive regulation of erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte development • positive regulation of peptidyl-tyrosine phosphorylation • Sertoli cell development • platelet aggregation • cellular response to cAMP • cellular response to follicle-stimulating hormone stimulus • transcriptional activation by promoter-enhancer looping • dendritic cell differentiation • cellular response to thyroid hormone stimulus • negative regulation of transcription regulatory region DNA binding
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2623 14460 Ensembl ENSG00000102145 ENSMUSG00000031162 UniProt P15976 P17679 RefSeq (mRNA) NM_002049.3 NM_008089.1 RefSeq (protein) NP_002040.1 NP_032115.1 Location (UCSC) Chr X:
48.64 – 48.65 Mb Chr X:
7.96 – 7.98 Mb PubMed search

Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the GATA1 gene.

GATA-1 is a member of the GATA transcription factor family and is involved in cell growth and cancer. This protein plays a role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.