Gambino is an Italian surname. Notable persons with that surname include:
- Some members of the Gambino crime family, including:
- Carlo Gambino, New York mobster and former boss of the crime family
- Emanuel Gambino, New York mobster and nephew of Carlo Gambino
- John Gambino, Sicilian mobster who operates in New Jersey
- Rosario Gambino, Sicilian mobster imprisoned on drug charges
- Thomas Gambino, son of Carlo Gambino and caporegime in the Gambino crime family
- Bizzy Bone, or Gambino, one of the many aliases for rapper Byron McCane
- Childish Gambino, stage name of actor Donald Glover
- Lu Gambino, American football player
- Salvatore Gambino, Italian-German football player
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