GABAB Receptor - Structure

Structure

GABABRs are similar in structure to and in the same receptor family with metabotropic glutamate receptors. There are two subtypes of the receptor, GABAB1 and GABAB2, and these appear to assemble as heterodimers in neuronal membranes by linking up by their intracellular C termini.

It is speculated that binding of GABA causes the subunits to swing shut around the agonist like a venus fly trap.

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