Cast
- Adam Sandler as George Simmons
- Seth Rogen as Ira Wright
- Leslie Mann as Laura
- Eric Bana as Clarke
- Jason Schwartzman as Mark Taylor Jackson
- Jonah Hill as Leo Koenig
- Aubrey Plaza as Daisy Danby
- RZA as Chuck
- Maude Apatow as Mable
- Iris Apatow as Ingrid
- Aziz Ansari as Randy Springs
- Torsten Voges as Dr. Lars
- Allan Wasserman as Dr. Stevens
- Steve Bannos as Deli Manager
- Eminem as himself
Dave Attell, Sarah Silverman, Norm Macdonald, Paul Reiser, Tom Anderson, Charles Fleischer, George Wallace, and Andy Dick made cameo appearances as themselves in the roles of George's fellow comedians. Rapper Eminem, comedian Ray Romano, musician James Taylor, MADtv member Nicole Parker, and newcomer Bo Burnham also appeared in small roles. Undeclared alum Carla Gallo had a cameo in the film as a character on Yo Teach!, the television show within the film that Mark stars in, while Justin Long and Apatow regular Ken Jeong have cameos in the film as characters in movies for which George is famous. Owen Wilson and Elizabeth Banks are featured on posters for fake movies in which George starred. Bryan Batt makes an appearance as George's agent. Musicians Jon Brion, Sebastian Steinberg, and James Gadson appear in the film as members of George's jam band. Comedians Rod Man, Budd Friedman, Monty Hoffman, Mark Schiff, Orny Adams, Al Lubel, and Jerry Minor appear as themselves. Comedienne/producer/writer Carol Leifer appears as herself.
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