Frederica is a feminine given name. Frederica also may refer to:
- Frederica (novel), a romance novel by Georgette Heyer
- Frederica, Delaware, United States
- Frederica Academy, an American school
- Fort Frederica, a historic American fort
- Frederica naval action, a small naval battle during the American Revolutionary War
- Frederica Bernkastel, a character in the Japanese sound novel Higurashi no Naku Koro ni.