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In 1806, Key's sister, Anne Phoebe Charlton Key, married Roger B. Taney, who would later become Chief Justice of the United States. In 1846 his daughter Alice married U.S. Senator George H. Pendleton. In 1859 Key's son Philip Barton Key II was shot and killed by Daniel Sickles—a U.S. Congressman who would serve as a general in the American Civil War—after he discovered that Philip Barton Key was having an affair with his wife. Sickles was acquitted in the first use of the temporary insanity defense. In 1861 Key's grandson Francis Key Howard was imprisoned in Fort McHenry with the Mayor of Baltimore George William Brown and other locals deemed pro-South.
Key was a distant cousin and the namesake of F. Scott Fitzgerald, whose full name was Francis Scott Key Fitzgerald. His direct descendants include geneticist Thomas Hunt Morgan, guitarist Dana Key, and American fashion designer and socialite Pauline de Rothschild.
Two of Key's religious poems used as Christian hymns include "Before the Lord We Bow" and "Lord, with Glowing Heart I'd Praise Thee".
Despite several efforts to preserve it, the Francis Scott Key residence was ultimately dismantled in 1947. The residence had been located at 3516–18 M Street in Georgetown.
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