Foxp2

FOXP2

Identifiers Symbols FOXP2; CAGH44; SPCH1; TNRC10 External IDs OMIM: 605317 MGI: 2148705 HomoloGene: 33482 GeneCards: FOXP2 Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • transcription factor binding • zinc ion binding • DNA binding, bending • protein homodimerization activity • sequence-specific DNA binding • protein heterodimerization activity
Cellular component	• nucleus • transcription factor complex • nucleolus • cytoplasm
Biological process	• positive regulation of mesenchymal cell proliferation • pattern specification process • skeletal muscle tissue development • embryo development • post-embryonic development • cerebellum development • caudate nucleus development • putamen development • cerebral cortex development • growth • vocal learning • camera-type eye development • negative regulation of transcription, DNA-dependent • lung alveolus development • smooth muscle tissue development • regulation of sequence-specific DNA binding transcription factor activity • righting reflex • positive regulation of epithelial cell proliferation involved in lung morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 93986 114142 Ensembl ENSG00000128573 ENSMUSG00000029563 UniProt O15409 P58463 RefSeq (mRNA) NM_001172766.2 NM_053242.4 RefSeq (protein) NP_001166237.1 NP_444472.2 Location (UCSC) Chr 7:
113.73 – 114.33 Mb Chr 6:
14.9 – 15.44 Mb PubMed search

Forkhead box protein P2 also known as FOXP2 is a protein that in humans is encoded by the FOXP2 gene, located on human chromosome 7 (7q31, at the SPCH1 locus). FOXP2 orthologs have also been identified in all mammals for which complete genome data are available. The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression. In addition to this characteristic forkhead-box domain, the protein contains a polyglutamine tract, a zinc finger and a leucine zipper.