FOXO3

FOXO3

Identifiers Symbols FOXO3; AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A External IDs OMIM: 602681 MGI: 1890081 HomoloGene: 31039 ChEMBL: 5778 GeneCards: FOXO3 Gene

Gene Ontology
Molecular function	• DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • DNA binding, bending • protein kinase binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex • cytoplasm • cytosol
Biological process	• negative regulation of transcription from RNA polymerase II promoter • ovulation from ovarian follicle • initiation of primordial ovarian follicle growth • antral ovarian follicle growth • oocyte maturation • regulation of translation • apoptotic process • induction of apoptosis • response to stress • response to DNA damage stimulus • epidermal growth factor receptor signaling pathway • pattern specification process • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • embryo development • tissue development • DNA damage response, signal transduction by p53 class mediator • regulation of cell proliferation • glucose homeostasis • positive regulation of erythrocyte differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • regulation of sequence-specific DNA binding transcription factor activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2309 56484 Ensembl ENSG00000118689 ENSMUSG00000048756 UniProt O43524 Q9WVH4 RefSeq (mRNA) NM_001455 NM_019740 RefSeq (protein) NP_001446 NP_062714 Location (UCSC) Chr 6:
108.88 – 109.01 Mb Chr 10:
42.18 – 42.28 Mb PubMed search

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.