Fkbp1b

FKBP1B

Identifiers Symbols FKBP1B; FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase External IDs OMIM: 600620 MGI: 1336205 HomoloGene: 68380 ChEMBL: 2430 GeneCards: FKBP1B Gene EC number 5.2.1.8

Gene Ontology
Molecular function	• peptidyl-prolyl cis-trans isomerase activity • receptor binding • ryanodine-sensitive calcium-release channel activity • protein binding • FK506 binding • ion channel binding
Cellular component	• cytosol • sarcoplasmic reticulum membrane • calcium channel complex
Biological process	• protein peptidyl-prolyl isomerization • 'de novo' protein folding • muscle contraction • smooth muscle contraction • response to glucose stimulus • negative regulation of heart rate • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • peptidyl-proline modification • neuronal action potential propagation • protein maturation by protein folding • insulin secretion • negative regulation of protein phosphatase type 2B activity • protein refolding • T cell proliferation • response to redox state • regulation of ryanodine-sensitive calcium-release channel activity • regulation of voltage-gated calcium channel activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2281 14226 Ensembl ENSG00000119782 ENSMUSG00000020635 UniProt P68106 Q9Z2I2 RefSeq (mRNA) NM_004116 NM_016863 RefSeq (protein) NP_004107 NP_058559 Location (UCSC) Chr 2:
24.27 – 24.29 Mb Chr 12:
4.83 – 4.84 Mb PubMed search

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.