Interactions
Fibroblast growth factor receptor 2 has been shown to interact with FGF1.
The spliced isoforms, however differ in binding:
- FGFR2IIIb binds to FGF-1, -3, -7, -10, -22
- FGFR2IIIc binds to FGF-1, -2, -4, -6, -8, -9, -17 and -18
These differences in binding are not surprising, since FGF ligand is known to bind to the second and third immunoglobulin domain of the receptor.
Read more about this topic: Fibroblast Growth Factor Receptor 2
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