Relations
The fastigial nucleus receives its afferent input from the vermis. Most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei, which is located at the junction of the pons and the medulla oblongata.
The fastigial nucleus contains excitatory axons which project beyond the cerebellum, unlike the Purkinje cells that convey the purely inhibitory output of the cerebellar cortex. The likely neurotransmitters of the excitatory fastigial nucleus axons are glutamate and aspartate.
The Purkinje cells of the cerbellar cortex project into the deep cerebellar nuclei and inhibit the excitatory output system.
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