Ewe or EWE may refer to:
- Ewe people, an ethnic group in Eastern part of Ghana, Benin and Togo
- Ewe music, music of the Ewe people
- Ewe language, the language of the Ewe people
- Ewe, a female sheep
- EWE: the station code for Ewell East railway station in Surrey, England
- EwE: Ecopath with Ecosim, an ecological computer modelling system for fisheries
- Edwin Washington Edwards, former Governor of Louisiana, USA
- David Ewe, New Zealand rugby player
- Isle of Ewe, an island off the west coast of Scotland
- St Ewe, village in Cornwall
- EWE Baskets Oldenburg, German basketball team
- EWE Arena in Oldenburg, Germany
- Ewer Airport, Indonesia (IATA code: EWE)