Enzyme Commission Number - Top Level Codes

Top Level Codes

Top-level EC numbers
Group Reaction catalyzed Typical reaction Enzyme example(s) with trivial name
EC 1
Oxidoreductases		 To catalyze oxidation/reduction reactions; transfer of H and O atoms or electrons from one substance to another AH + B → A + BH
A + O → AO 		Dehydrogenase, oxidase
EC 2
Transferases		 Transfer of a functional group from one substance to another. The group may be methyl-, acyl-, amino- or phosphate group AB + C → A + BC Transaminase, kinase
EC 3
Hydrolases		 Formation of two products from a substrate by hydrolysis AB + H2O → AOH + BH Lipase, amylase, peptidase
EC 4
Lyases		 Non-hydrolytic addition or removal of groups from substrates. C-C, C-N, C-O or C-S bonds may be cleaved RCOCOOH → RCOH + CO2 or → Decarboxylase
EC 5
Isomerases		 Intramolecule rearrangement, i.e. isomerization changes within a single molecule AB → BA Isomerase, mutase
EC 6
Ligases		 Join together two molecules by synthesis of new C-O, C-S, C-N or C-C bonds with simultaneous breakdown of ATP X + Y+ ATP → XY + ADP + Pi Synthetase

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