Endogenous mediators are intracellular proteins that enhance and activate the functions of other proteins. This term is commonly used in molecular biology and cell biology to describe a specific protein complex that acts in transcription as a coactivator. This Mediator complex is located within the cell nucleus.
The Mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast. It works in the same manner in mammals. The mediator functions as a coactivator and binds to the C-terminal domain of RNA polymerase II holoenzyme, acting as a bridge between this enzyme and transcription factors.
Famous quotes containing the word mediator:
“Their errors have been weighed and found to have been dust in the balance; if their sins were as scarlet, they are now white as snow: they have been washed in the blood of the mediator and the redeemer, Time.”
—Percy Bysshe Shelley (1792–1822)