2012
Makarova started her year at the 2012 Australian Open. In the second round, she defeated #25 seed Kaia Kanepi 6–4, 6–2. Then in the third round, she defeated #7 seed Vera Zvonareva 7–6, 6–1. In the Round of 16, she defeated 13-time Grand Slam champion Serena Williams convincingly 6–2, 6–3, to advance to her first Grand Slam Quarterfinal of her career. There, she faced #4 seed and former champion Maria Sharapova and was throttled 0–6, 2–6 by the eventual finalist. She reached the semi-finals of Aegon Classic 2012, losing to Melanie Oudin, 6–4 3–6 6–2.
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