Egr1

EGR1

Identifiers Symbols EGR1; AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225 External IDs OMIM: 128990 MGI: 95295 HomoloGene: 56394 GeneCards: EGR1 Gene

Gene Ontology
Molecular function	• transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity • DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • histone acetyltransferase binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • learning or memory • response to glucose stimulus • cytokine-mediated signaling pathway • T cell differentiation • BMP signaling pathway • response to insulin stimulus • regulation of protein sumoylation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of long-term neuronal synaptic plasticity • type I interferon-mediated signaling pathway • interleukin-1-mediated signaling pathway • cellular response to gamma radiation • cellular response to heparin • cellular response to mycophenolic acid • glomerular mesangial cell proliferation • positive regulation of glomerular metanephric mesangial cell proliferation • negative regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1958 13653 Ensembl ENSG00000120738 ENSMUSG00000038418 UniProt P18146 P08046 RefSeq (mRNA) NM_001964.2 NM_007913.5 RefSeq (protein) NP_001955.1 NP_031939.1 Location (UCSC) Chr 5:
137.8 – 137.81 Mb Chr 18:
34.86 – 34.86 Mb PubMed search

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.