Egnatia can refer to:
- Gnatia, an ancient town in southern Italy.
- two municipalities in Greece:
- Egnatia, Ioannina, in the Ioannina regional unit
- Egnatia, Thessaloniki, in the Thessaloniki regional unit
- Via Egnatia, an ancient Roman road in Illyria, Macedonia and Thrace
- Egnatia Odos (modern road), a modern highway in northern Greece
- KS Egnatia, a football team based in Rrogozhinë, Albania