EGLN1

EGLN1

Identifiers Symbols EGLN1; C1orf12; ECYT3; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM20; ZMYND6 External IDs OMIM: 606425 HomoloGene: 56936 ChEMBL: 5697 GeneCards: EGLN1 Gene EC number 1.14.11.29

Gene Ontology
Molecular function	• iron ion binding • protein binding • zinc ion binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • L-ascorbic acid binding • peptidyl-proline dioxygenase activity • peptidyl-proline 4-dioxygenase activity
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• response to hypoxia • peptidyl-proline hydroxylation to 4-hydroxy-L-proline • oxygen homeostasis • cellular response to stress • negative regulation of sequence-specific DNA binding transcription factor activity • regulation of angiogenesis • cardiac muscle tissue morphogenesis • heart trabecula formation • ventricular septum morphogenesis • labyrinthine layer development • regulation of transcription from RNA polymerase II promoter in response to hypoxia • cellular response to hypoxia • response to nitric oxide
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 54583 112405 Ensembl ENSG00000135766 ENSMUSG00000031987 UniProt Q9GZT9 Q91YE3 RefSeq (mRNA) NM_022051 NM_053207 RefSeq (protein) NP_071334 NP_444437 Location (UCSC) Chr 1:
231.5 – 231.56 Mb Chr 8:
124.91 – 124.95 Mb PubMed search

Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme encoded by the EGLN1 gene. It is also known as Egl nine homolog 1.