Research
Dr. Krieger's main research field is the study of experimental hypertension in animal models and the physiological mechanisms of blood pressure regulation, mainly its neurogenic mechanisms. He described a method for performing the denervation of the sino-aortic baroceptor in the Norwegian rat which is widely used. His studies on the baroreceptor adaptation in hypertension and hypotension are widely recognized and have been published in the main scientific journals of the field. Dr. Krieger is one of the most highly cited Brazilian researchers.
He was also a pioneer in using the rat as a model for the study of blood pressure regulation in sleep and exercise, as well as in the neural recording of electrical activity of the sympathetic system in physiological conditions. In collaboration with Prof. Sérgio Henrique Ferreira in the last phase of the discovery of a new ACE inhibitor extracted from Bothrops venom, he demonstrated experimentally its efficacy in the reversion of experimental hypertension, thus opening the way for the eventual development of a new antihypertensive drug, captopril (trademarked Capoten) by Squibb scientists.
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