DPN may refer to:
- Deaf President Now, a 1988 student protest at Gallaudet University to force the university to hire a deaf president
- Democratic Party of Nauru, a political party in the Pacific nation of Nauru
- Dermatosis papulosa nigra, a skin condition
- Designated Portsmouth Number, a measure in the Portsmouth Yardstick system of handicapping for dissimilar boats in a race
- Diphosphopyridine nucleotide, an old name for Nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells
- Dip-pen nanolithography, a scanning probe lithography technique
- Double Pointed Needles, a type of knitting needle