Function
This gene encodes the D2 subtype of the dopamine receptor. This G protein-coupled receptor inhibits adenylyl cyclase activity.
Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
In mice, regulation of D2R surface expression by the calcium sensor NCS-1 in the dentate gyrus controls exploration, synaptic plasticity and memory formation.
Read more about this topic: Dopamine Receptor D2
Famous quotes containing the word function:
“For me being a poet is a job rather than an activity. I feel I have a function in society, neither more nor less meaningful than any other simple job. I feel it is part of my work to make poetry more accessible to people who have had their rights withdrawn from them.”
—Jeni Couzyn (b. 1942)
“The uses of travel are occasional, and short; but the best fruit it finds, when it finds it, is conversation; and this is a main function of life.”
—Ralph Waldo Emerson (1803–1882)
“No one, however powerful and successful, can function as an adult if his parents are not satisfied with him.”
—Frank Pittman (20th century)