Dopamine Receptor D2

Dopamine Receptor D2

Identifiers Symbols DRD2; D2DR; D2R External IDs OMIM: 126450 MGI: 94924 HomoloGene: 22561 IUPHAR: D₂ ChEMBL: 217 GeneCards: DRD2 Gene

Gene Ontology
Molecular function	• dopamine neurotransmitter receptor activity, coupled via Gi/Go • protein binding • drug binding • potassium channel regulator activity • dopamine binding • ionotropic glutamate receptor binding
Cellular component	• acrosomal vesicle • plasma membrane • integral to plasma membrane • postsynaptic density • lateral plasma membrane • endocytic vesicle • axon • dendrite • synaptic vesicle membrane • perikaryon • axon terminus
Biological process	• temperature homeostasis • response to hypoxia • synaptic transmission, dopaminergic • response to amphetamine • neurological system process involved in regulation of systemic arterial blood pressure • regulation of heart rate • regulation of sodium ion transport • G-protein coupled receptor internalization • positive regulation of neuroblast proliferation • positive regulation of receptor internalization • cellular calcium ion homeostasis • negative regulation of adenylate cyclase activity • adenylate cyclase-inhibiting dopamine receptor signaling pathway • intracellular protein kinase cascade • neuron-neuron synaptic transmission • axonogenesis • synapse assembly • sensory perception of smell • long-term memory • grooming behavior • locomotory behavior • adult walking behavior • feeding behavior • protein localization • negative regulation of cell proliferation • associative learning • visual learning • response to light stimulus • response to toxin • response to iron ion • regulation of dopamine secretion • Wnt receptor signaling pathway • cerebral cortex GABAergic interneuron migration • adenohypophysis development • negative regulation of cell migration • peristalsis • regulation of cAMP metabolic process • auditory behavior • activation of protein kinase activity • regulation of synaptic transmission, GABAergic • circadian regulation of gene expression • response to histamine • response to nicotine • positive regulation of urine volume • positive regulation of renal sodium excretion • positive regulation of multicellular organism growth • response to cocaine • negative regulation of circadian sleep/wake cycle, sleep • dopamine metabolic process • response to drug • regulation of potassium ion transport • response to morphine • pigmentation • regulation of phosphoprotein phosphatase activity • positive regulation of G-protein coupled receptor protein signaling pathway • negative regulation of blood pressure • positive regulation of transcription from RNA polymerase II promoter • phosphatidylinositol metabolic process • negative regulation of insulin secretion • behavioral response to cocaine • behavioral response to ethanol • regulation of long-term neuronal synaptic plasticity • response to axon injury • branching morphogenesis of a nerve • arachidonic acid secretion • negative regulation of protein secretion • release of sequestered calcium ion into cytosol • reduction of cytosolic calcium ion concentration • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • positive regulation of dopamine uptake involved in synaptic transmission • negative regulation of protein kinase B signaling cascade • negative regulation of synaptic transmission, glutamatergic • positive regulation of growth hormone secretion • prepulse inhibition • phospholipase C-activating dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • negative regulation of voltage-gated calcium channel activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1813 13489 Ensembl ENSG00000149295 ENSMUSG00000032259 UniProt P14416 P61168 RefSeq (mRNA) NM_000795 NM_010077 RefSeq (protein) NP_000786 NP_034207 Location (UCSC) Chr 11:
113.28 – 113.35 Mb Chr 9:
49.34 – 49.41 Mb PubMed search

Dopamine receptor D₂, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.