History
The Russian ichthyologist Lev Berg proposed directed mass mutations as the main mechanism for evolution in his anti-Darwinian book Nomogenesis; or, Evolution Determined by Law (1922). Early studies of "directed mutation" were performed by German geneticists. Richard Goldschmidt in 1929 due to his experiments on drosophila through exposure to elevated temperatures had claimed to have produced evidence for directed mutation. Viktor Jollos (1887-1941) in the 1930s had also carried out experiments on drosophila and written that his results had confirmed Goldschmidt's work which was evidence for direct mutation in contrast to natural selection. However later American geneticists were unable to replicate these experiments.
Read more about this topic: Directed Mutagenesis
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