Diablo is a word in Spanish meaning "devil". It may refer to:
- Devil, a supernatural entity believed in many religions and cultures to be the personification of evil and the enemy of God and humankind
- Diablos MC, a motorcycle club
- Lamborghini Diablo, an Italian sports car
- Diablo Data Systems, a division of Xerox
- Diablo 630, a daisy wheel printer
- USS Diablo (SS-479), an American submarine
- Diablo wind, a type of hot, dry wind
- Diablo homolog, a gene
- Diablos, name for Mission Viejo High School sports teams
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