Diablo is a word in Spanish meaning "devil". It may refer to:

  • Devil, a supernatural entity believed in many religions and cultures to be the personification of evil and the enemy of God and humankind
  • Diablos MC, a motorcycle club
  • Lamborghini Diablo, an Italian sports car
  • Diablo Data Systems, a division of Xerox
    • Diablo 630, a daisy wheel printer
  • USS Diablo (SS-479), an American submarine
  • Diablo wind, a type of hot, dry wind
  • Diablo homolog, a gene
  • Diablos, name for Mission Viejo High School sports teams

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