The initialism DFL can stand for the following:
- Money and finance
- Degree of Financial Leverage Leverage (finance)
- Dutch guilder, Dfl, from 'Dutch florin'
- Education and research
- Danmarks Lærerforening, the Danish Union of Teachers
- David Florida Laboratory, a Canadian aerospace laboratory
- Deutsche Forschungsanstalt für Luftfahrt, a former research institute in Braunschweig, Germany
- Politics and activism
- Minnesota Democratic–Farmer–Labor Party, an affiliate of the U.S. Democratic Party
- Democrats for Life, an organization of pro-life Democrats
- Other
- Design for logistics, a supply-chain management concept
- Deutsche Fußball Liga, operator of the German Fußball-Bundesliga
- Double Four Long-distance, a version of the Cosworth DFV racing engine developed for racing in Group 5/6 cars
- Dunfermline Queen Margaret railway station, Scotland, which has the National Rail station code DFL