Desmond may refer to:
- Desmond (name), a common given name and surname
- Kingdom of Desmond, medieval Irish kingdom
- Earl of Desmond, Irish aristocratic title
- Desmond Rebellions, Irish rebellions during the 16th century led by the Earl of Desmond
- Desmond's, 1990s British sitcom, screened by Channel 4
- Desmond, slang term for the British 2:2 degree classification
- DESMOND (Diabetes Education and Self Management for Ongoing and Newly Diagnosed) a UK NHS diabetes education programme
- Desmond software, which performs high-speed molecular dynamics simulations.
- Desmond (novel), 1792 novel by Charlotte Turner Smith
- Desmond Miles, a fictional character in the Assassin's Creed video game franchise