Professional Boxing Record
| 50 Wins (44 knockouts, 5 decisions, 1 disqualification), 6 Losses, 0 Draws, 2 No Contests | |||||||
| Res. | Record | Opponnent | Type | Rd., Time | Date | Location | Notes |
| Loss | 50–6-(2) | Kevin McBride | TKO | 6 (10), 3:00 | 2005-06-11 | MCI Center, Washington, D.C. | |
| Loss | 50–5-(2) | Danny Williams | KO | 4 (10), 2:51 | 2004-07-30 | Freedom Hall State Fairground, Louisville, Kentucky | |
| Win | 50–4-(2) | Clifford Etienne | KO | 1 (10), 0:49 | 2003-02-22 | The Pyramid, Memphis, Tennessee | |
| Loss | 49–4-(2) | Lennox Lewis | KO | 8 (12), 2:25 | 2002-06-08 | The Pyramid, Memphis, Tennessee | For The Ring, WBC, IBO & IBF Heavyweight titles. The Ring Magazine Knockout of the Year. |
| Win | 49–3-(2) | Brian Nielsen | RTD | 7 (10), 3:00 | 2001-10-13 | Parken Stadium, Copenhagen | |
| NC | 48–3-(2) | Andrew Golota | NC | 3 (10) | 2000-10-20 | The Palace, Auburn Hills, Michigan | Changed to No Contest after Tyson's post-fight drug test positive for cannabis. |
| Win | 48–3-(1) | Lou Savarese | TKO | 1 (10), 0:38 | 2000-06-24 | Hampden Park, Glasgow | |
| Win | 47–3-(1) | Julius Francis | TKO | 2 (10), 1:03 | 2000-01-29 | M.E.N. Arena, Manchester | |
| NC | 46–3-(1) | Orlin Norris | NC | 1 (10), 3:00 | 1999-10-23 | MGM Grand Garden Arena, Las Vegas, Nevada | Tyson hit Norris after the bell. Norris was knocked down, injuring his knee in the fall, and was unable to continue. |
| Win | 46–3 | Francois Botha | KO | 5 (10), 2:59 | 1999-01-16 | MGM Grand Garden Arena, Las Vegas, Nevada | |
| Loss | 45–3 | Evander Holyfield | DQ | 3 (12) | 1997-06-28 | MGM Grand Garden Arena, Las Vegas, Nevada | For WBA Heavyweight title. The Ring Magazine Event of the Year. |
| Loss | 45–2 | Evander Holyfield | TKO | 11 (12), 0:37 | 1996-11-09 | MGM Grand Garden Arena, Las Vegas, Nevada | Lost WBA Heavyweight title. The Ring Magazine Fight of the Year & Upset of the Year. |
| Win | 45–1 | Bruce Seldon | TKO | 1 (12), 1:49 | 1996-09-07 | MGM Grand Garden Arena, Las Vegas, Nevada | Won WBA Heavyweight title. |
| Win | 44–1 | Frank Bruno | TKO | 3 (12), 0:50 | 1996-03-16 | MGM Grand Garden Arena, Las Vegas, Nevada | Won WBC Heavyweight title. |
| Win | 43–1 | Buster Mathis, Jr. | KO | 3 (12), 2:32 | 1995-12-16 | Core States Spectrum, Philadelphia, Pennsylvania | |
| Win | 42–1 | Peter McNeeley | DQ | 1 (10), 1:29 | 1995-08-19 | MGM Grand Garden Arena, Las Vegas, Nevada | |
| Win | 41–1 | Donovan Ruddock | UD | 12 | 1991-06-28 | Mirage Hotel & Casino, Las Vegas, Nevada | |
| Win | 40–1 | Donovan Ruddock | TKO | 7 (12), 2:22 | 1991-03-18 | Mirage Hotel & Casino, Las Vegas, Nevada | |
| Win | 39–1 | Alex Stewart | TKO | 1 (10), 2:27 | 1990-12-08 | Convention Center, Atlantic City, New Jersey | |
| Win | 38–1 | Henry Tillman | KO | 1 (10), 2:47 | 1990-06-16 | Caesars Palace, Las Vegas, Nevada | |
| Loss | 37–1 | Buster Douglas | KO | 11 (12), 1:22 | 1990-02-11 | Tokyo Dome, Tokyo | Lost The Ring, WBC, WBA & IBF Heavyweight titles. The Ring Magazine Upset of the Year. |
| Win | 37–0 | Carl Williams | TKO | 1 (12), 1:33 | 1989-07-21 | Convention Center, Atlantic City, New Jersey | Retained The Ring, WBC, WBA & IBF Heavyweight titles. |
| Win | 36–0 | Frank Bruno | TKO | 5 (12), 2:55 | 1989-02-25 | Hilton Hotel, Las Vegas, Nevada | Retained The Ring, WBC, WBA & IBF Heavyweight titles. |
| Win | 35–0 | Michael Spinks | KO | 1 (12), 1:31 | 1988-06-27 | Convention Hall, Atlantic City, New Jersey | Retained WBC, WBA, IBF & won The Ring Heavyweight titles. |
| Win | 34–0 | Tony Tubbs | TKO | 2 (12), 2:54 | 1988-03-21 | Tokyo Dome, Tokyo | Retained WBC, WBA & IBF Heavyweight titles. |
| Win | 33–0 | Larry Holmes | TKO | 4 (12), 2:55 | 1988-01-22 | Convention Hall, Atlantic City, New Jersey | Retained WBC, WBA & IBF Heavyweight titles. |
| Win | 32–0 | Tyrell Biggs | TKO | 7 (12), 2:59 | 1987-10-16 | Convention Hall, Atlantic City, New Jersey | Retained WBC, WBA & IBF Heavyweight titles. |
| Win | 31–0 | Tony Tucker | UD | 12 | 1987-08-01 | Hilton Hotel, Las Vegas, Nevada | Retained WBC, WBA & won IBF Heavyweight titles. |
| Win | 30–0 | Pinklon Thomas | TKO | 6 (12), 2:00 | 1987-05-30 | Hilton Hotel, Las Vegas, Nevada | Retained WBC & WBA Heavyweight titles. |
| Win | 29–0 | James Smith | UD | 12 | 1987-03-07 | Hilton Hotel, Las Vegas, Nevada | Retained WBC & won WBA Heavyweight titles. |
| Win | 28–0 | Trevor Berbick | TKO | 2 (12), 2:35 | 1986-11-22 | Hilton Hotel, Las Vegas, Nevada | Won WBC Heavyweight title. |
| Win | 27–0 | Alfonso Ratliff | TKO | 2 (10), 1:41 | 1986-09-06 | Hilton Hotel, Las Vegas, Nevada | |
| Win | 26–0 | José Ribalta | TKO | 10 (10), 1:37 | 1986-08-17 | Trump Plaza Hotel, Atlantic City, New Jersey | |
| Win | 25–0 | Marvis Frazier | KO | 1 (10), 0:30 | 1986-07-26 | Civic Center, Glens Falls, New York | |
| Win | 24–0 | Lorenzo Boyd | KO | 2 (10), 1:43 | 1986-07-11 | Stevensville Hotel, Swan Lake, New York | |
| Win | 23–0 | William Hosea | KO | 1 (10), 2:03 | 1986-06-28 | Houston Field House, Troy, New York | |
| Win | 22–0 | Reggie Gross | TKO | 1 (10), 2:36 | 1986-06-13 | Madison Square Garden, New York, New York | |
| Win | 21–0 | Mitch Green | UD | 10 | 1986-05-20 | Madison Square Garden, New York, New York | |
| Win | 20–0 | James Tillis | UD | 10 | 1986-05-09 | Civic Center, Glens Falls, New York | |
| Win | 19–0 | Steve Zouski | KO | 3 (10), 2:39 | 1986-03-10 | Nassau Coliseum, Uniondale, New York | |
| Win | 18–0 | Jesse Ferguson | TKO | 6 (10), 1:19 | 1986-02-16 | Houston Field House, Troy, New York | |
| Win | 17–0 | Mike Jameson | TKO | 5 (8), 0:46 | 1986-01-24 | Trump Plaza Hotel, Atlantic City, New Jersey | |
| Win | 16–0 | David Jaco | TKO | 1 (10), 2:16 | 1986-01-11 | Plaza Convention Center, Albany, New York | |
| Win | 15–0 | Mark Young | TKO | 1 (10), 0:50 | 1985-12-27 | Latham Coliseum, Latham, New York | |
| Win | 14–0 | Sammy Scaff | TKO | 1 (10), 1:19 | 1985-12-06 | Felt Forum, New York, New York | |
| Win | 13–0 | Conroy Nelson | TKO | 2 (8), 0:30 | 1985-11-22 | Latham Coliseum, Latham, New York | |
| Win | 12–0 | Eddie Richardson | KO | 1 (8), 1:17 | 1985-11-13 | Ramada-Houston Hotel, Houston, Texas | |
| Win | 11–0 | Sterling Benjamin | TKO | 1 (8), 0:54 | 1985-11-01 | Latham Coliseum, Latham, New York | |
| Win | 10–0 | Robert Colay | KO | 1 (8), 0:37 | 1985-10-25 | Atlantis Hotel & Casino, Atlantic City, New Jersey | |
| Win | 9–0 | Donnie Long | TKO | 1 (6), 1:28 | 1985-10-09 | Trump Casino Hotel, Atlantic City, New Jersey | |
| Win | 8–0 | Michael Johnson | KO | 1 (6), 0:39 | 1985-09-05 | Atlantis Hotel & Casino, Atlantic City, New Jersey | |
| Win | 7–0 | Lorenzo Canady | KO | 1 (6), 1:05 | 1985-08-15 | Resorts International, Atlantic City, New Jersey | |
| Win | 6–0 | Larry Sims | KO | 3 (6), 2:04 | 1985-07-19 | Mid-Hudson Civic Center, Poughkeepsie, New York | |
| Win | 5–0 | John Alderson | TKO | 2 (6), 3:00 | 1985-07-11 | Trump Casino Hotel, Atlantic City, New Jersey | |
| Win | 4–0 | Ricardo Spain | TKO | 1 (6), 0:39 | 1985-06-20 | Resorts International, Atlantic City, New Jersey | |
| Win | 3–0 | Don Halpin | KO | 4 (4), 1:04 | 1985-05-23 | Albany, New York | |
| Win | 2–0 | Trent Singleton | TKO | 1 (4), 0:52 | 1985-04-10 | Albany, New York | |
| Win | 1–0 | Hector Mercedes | TKO | 1 (4), 1:47 | 1985-03-06 | Plaza Convention Center, Albany, New York | Professional debut. |
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