Development
The dentate nucleus is highly convoluted, and gyral, or groove, formation is coincident with a critical period of extensive growth in the fetal dentate. The dentate nucleus becomes visible in the cerebellar white matter as early as 11-12 weeks of gestation, containing only smooth lateral and medial surfaces. During this time, the neurons of the dentate nucleus are similar in shape and form, being mainly bipolar cells.
During 22-28 weeks of gestation, which is the critical period in fetal development of the dentate nucleus, gyral formation occurs extensively over the entire surface. Here, neurons mature into various forms of multipolar cells, and the most frequent neuronal types are medium sized to large neurons.
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