Factors Affecting Reaction Kinetics
The Dakin oxidation has two rate-limiting steps: nucleophilic addition of hydroperoxide to the carbonyl carbon and -aryl migration. Therefore, the overall rate of oxidation is dependent on the nucleophilicity of hydroperoxide, the electrophilicity of the carbonyl carbon, and the speed of -aryl migration. The alkyl substituents on the carbonyl carbon, the relative positions of the hydroxyl and carbonyl groups on the aryl ring, the presence of other functional groups on the ring, and the reaction mixture pH are four factors that affect these rate-limiting steps.
Read more about this topic: Dakin Oxidation
Famous quotes containing the words factors, affecting and/or reaction:
“Language makes it possible for a child to incorporate his parents’ verbal prohibitions, to make them part of himself....We don’t speak of a conscience yet in the child who is just acquiring language, but we can see very clearly how language plays an indispensable role in the formation of conscience. In fact, the moral achievement of man, the whole complex of factors that go into the organization of conscience is very largely based upon language.”
—Selma H. Fraiberg (20th century)
“It is a relief to read some true book, wherein all are equally dead,—equally alive. I think the best parts of Shakespeare would only be enhanced by the most thrilling and affecting events. I have found it so. And so much the more, as they are not intended for consolation.”
—Henry David Thoreau (1817–1862)
“In a land which is fully settled, most men must accept their local environment or try to change it by political means; only the exceptionally gifted or adventurous can leave to seek his fortune elsewhere. In America, on the other hand, to move on and make a fresh start somewhere else is still the normal reaction to dissatisfaction and failure.”
—W.H. (Wystan Hugh)