CYP3A4

CYP3A4

Identifiers Symbols CYP3A4; CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; MGC126680; NF-25; P450C3; P450PCN1 External IDs OMIM: 124010 HomoloGene: 111391 GeneCards: CYP3A4 Gene EC number 1.14.13.97

Gene Ontology
Molecular function	• monooxygenase activity • monooxygenase activity • steroid binding • iron ion binding • steroid hydroxylase activity • electron carrier activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • oxygen binding • enzyme binding • heme binding • vitamin D3 25-hydroxylase activity • taurochenodeoxycholate 6alpha-hydroxylase activity • caffeine oxidase activity • metal ion binding • albendazole monooxygenase activity • quinine 3-monooxygenase activity • testosterone 6-beta-hydroxylase activity • vitamin D 24-hydroxylase activity
Cellular component	• cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • microsome • cell surface • membrane • integral to membrane
Biological process	• lipid metabolic process • steroid catabolic process • xenobiotic metabolic process • steroid metabolic process • androgen metabolic process • alkaloid catabolic process • monoterpenoid metabolic process • drug metabolic process • vitamin D metabolic process • drug catabolic process • drug catabolic process • exogenous drug catabolic process • heterocycle metabolic process • oxidation-reduction process • oxidative demethylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1576 13112 Ensembl ENSG00000160868 ENSMUSG00000056035 UniProt P08684 Q64459 RefSeq (mRNA) NM_001202855.2 NM_007818.3 RefSeq (protein) NP_001189784.1 NP_031844.1 Location (UCSC) Chr 7:
99.35 – 99.38 Mb Chr 5:
146.67 – 146.69 Mb PubMed search

Cytochrome P₄₅₀ 3A4 (abbreviated CYP3A4) (EC 1.14.13.97), a member of the cytochrome P₄₅₀ mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the human body, constituting twenty-eight percent of total CYPs in the human body. CYP3A4 is involved in the oxidation of the largest range of substrates of all the CYPs. As a result, CYP3A4 is present in the largest quantity of all the CYPs in the liver. In humans, the CYP3A4 protein is encoded by the CYP3A4 gene. This gene is part of a cluster of cytochrome P₄₅₀ genes on chromosome 7q21.1.