CYP2E1

CYP2E1

Identifiers Symbols CYP2E1; CPE1; CYP2E; P450-J; P450C2E External IDs OMIM: 124040 MGI: 88607 HomoloGene: 68089 ChEMBL: 5281 GeneCards: CYP2E1 Gene EC number 1.14.13.n7

Gene Ontology
Molecular function	• monooxygenase activity • iron ion binding • electron carrier activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • oxygen binding • enzyme binding • heme binding
Cellular component	• endoplasmic reticulum membrane
Biological process	• xenobiotic metabolic process • steroid metabolic process • monoterpenoid metabolic process • drug metabolic process • small molecule metabolic process • heterocycle metabolic process • oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1571 13106 Ensembl ENSG00000130649 ENSMUSG00000025479 UniProt P05181 Q05421 RefSeq (mRNA) NM_000773.3 NM_021282.2 RefSeq (protein) NP_000764.1 NP_067257.1 Location (UCSC) Chr 10:
135.33 – 135.37 Mb Chr 7:
140.76 – 140.77 Mb PubMed search

Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP2E1 enzyme is encoded by the CYP2E1 gene. While it is involved in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are many important drug interactions mediated by CYP2E1.

Most drugs undergo deactivation by CYP2E1, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYP2E1 to form their active compounds (for examples - see table below)

CYP2E1, as well as alcohol dehydrogenase and aldehyde dehydrogenase, is an important enzyme for the conversion of ethanol to acetaldehyde and to acetate in humans.