CYP2D6

CYP2D6

Identifiers Symbols CYP2D6; CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 External IDs OMIM: 124030 MGI: 1929474 HomoloGene: 86099 GeneCards: CYP2D6 Gene EC number 1.14.14.1

Gene Ontology
Molecular function	• monooxygenase activity • iron ion binding • drug binding • electron carrier activity • oxidoreductase activity • heme binding • aromatase activity
Cellular component	• mitochondrion • endoplasmic reticulum • endoplasmic reticulum membrane
Biological process	• xenobiotic metabolic process • steroid metabolic process • coumarin metabolic process • alkaloid metabolic process • alkaloid catabolic process • monoterpenoid metabolic process • drug metabolic process • isoquinoline alkaloid metabolic process • drug catabolic process • small molecule metabolic process • heterocycle metabolic process • negative regulation of binding • oxidation-reduction process • oxidative demethylation • negative regulation of cellular organofluorine metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1565 13101 Ensembl ENSG00000100197 ENSMUSG00000094806 UniProt P10635 P24456 RefSeq (mRNA) NM_000106.5 NM_010005.3 RefSeq (protein) NP_000097.3 NP_034135.2 Location (UCSC) Chr 22:
42.52 – 42.53 Mb Chr 15:
82.4 – 82.41 Mb PubMed search

Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Also, many substances are bioactivated by CYP2D6 to form their active compounds. While CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.