Side Effects
Meta-analysis studies have found significantly increased rates of drowsiness (38% of patients), dry mouth (24%), dizziness (10%), and adverse events of any kind in patients taking cyclobenzaprine versus placebo. Drowsiness and dry mouth appear to intensify with increasing dose.
Other side effects are not significantly more common than they are in patients taking placebo. Some of these include blurred vision, fatigue, nausea, and headache. The sedative effects of cyclobenzaprine are likely due to its antagonistic effect on histamine, serotonin, and muscarinic receptors. Agitation is a common side effect observed especially in the elderly. In general, the NCQA recommends avoiding the use of cyclobenzaprine in the elderly because of the potential for more severe side effects. There is one case report of overdose causing rhabdomyolysis (muscle breakdown). Treatment protocols and support should follow the same as for any structurally related tricyclic, such as tricyclic antidepressants.
Read more about this topic: Cyclobenzaprine
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