Types
Table 1: Known CDKs, their cyclin partners, and their functions in the human and consequences of deletion in mice.
| CDK | Cyclin partner | Function | Deletion Phenotype in Mice |
|---|---|---|---|
| Cdk1 | Cyclin B | M phase | None. ~E2.5. |
| Cdk2 | Cyclin E | G1/S transition | Reduced size, imparted neural progenitor cell proliferation. Viable, but both males & females sterile. |
| Cdk2 | Cyclin A | S phase, G2 phase | |
| Cdk3 | Cyclin C | G1 phase ? | No defects. Viable, fertile. |
| Cdk4 | Cyclin D | G1 phase | Reduced size, insulin deficient diabetes. Viable, but both male & female infertile. |
| Cdk5 | p35 | Transcription | Severe neurological defects. Died immediately after birth. |
| Cdk6 | Cyclin D | G1 phase | |
| Cdk7 | Cyclin H | CDK-activating kinase, transcription | |
| Cdk8 | Cyclin C | Transcription | |
| Cdk9 | Cyclin T | Transcription | Embryonic lethal |
| Cdk11 | Cyclin L | ? | Mitotic defects. E3.5. |
| ? | Cyclin F | ? | Defects in extraembryonic tissues. E10.5. |
| ? | Cyclin G | ? |
Read more about this topic: Cyclin-dependent Kinase
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