Cyanuric Chloride - Organic Synthesis

Organic Synthesis

In one specialized application, cyanuric chloride is employed as a reagent in organic synthesis for the conversion of alcohols and carboxylic acids into alkyl and acyl chlorides, respectively:

It is also used as a dehydrating agent and for the activation of carboxylic acids for reduction to alcohols. Heating with DMF gives "Gold's reagent" Me2NCH=NCH=NMe2+Cl-, which is a versatile source of aminoalkylations and a precursor to heterocycles.

The chloride centers are easily replaced by amines to give melamine derivatives, for example in the synthesis of dendrimers:

It is also employed the synthesis of an experimental adenosine receptor ligand.:

Cyanuric Chloride can also be used as an alternative to oxalyl chloride in the Swern oxidation.

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