Cuyahoga may mean:
- Cuyahoga County, Ohio
- Cuyahoga Falls, Ohio
- Cuyahoga Heights, Ohio
- Cuyahoga River
- Cuyahoga Valley National Park
- USCGC Cuyahoga (WIX-157), a U.S. Coast Guard Cutter that sank in the Chesapeake Bay in 1978 after a collision with a freighter
- "Cuyahoga", an open source .NET Web site framework that provides content management capabilities and has a modular approach.
- "Cuyahoga", a song by R.E.M. on their 1986 album Lifes Rich Pageant.