Cushing's disease (also known as tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease) is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercorticism). This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism). Pituitary adenomas are responsible for 70% of endogenous Cushing's syndrome, that is, when excluding Cushing's syndrome from exogenously administered corticosteroids, which is the major cause of Cushing's syndrome.
This is not to be confused with Ectopic Cushing syndrome.
Read more about Cushing's Disease: Signs and Symptoms, History, Diagnosis, Treatment
Famous quotes containing the words cushing and/or disease:
“She finally got Harry all to herself.”
—Mark Hanna. Nathan Hertz. Dr. Cushing (Roy Gordon)
“Is not disease the rule of existence? There is not a lily pad floating on the river but has been riddled by insects. Almost every shrub and tree has its gall, oftentimes esteemed its chief ornament and hardly to be distinguished from the fruit. If misery loves company, misery has company enough. Now, at midsummer, find me a perfect leaf or fruit.”
—Henry David Thoreau (1817–1862)