Cushing's disease (also known as tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease) is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercorticism). This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (tertiary hypercortisolism/hypercorticism). Pituitary adenomas are responsible for 70% of endogenous Cushing's syndrome, that is, when excluding Cushing's syndrome from exogenously administered corticosteroids, which is the major cause of Cushing's syndrome.
This is not to be confused with Ectopic Cushing syndrome.
Read more about Cushing's Disease: Signs and Symptoms, History, Diagnosis, Treatment
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