Cuatro is Spanish (and other Romance languages) for the number four. It may also refer to:
- Cuatro (instrument), Name for two distinct Latin American instruments one from Puerto Rico and the other from Venezuela
- Cuatro (TV channel) ("Four"), is a Spanish private, free-to-air broadcast television channel owned by Mediaset
- TV Cuatro (TVCU4TRO), is the brand name of TV4 León (XHLEG-TV), the public broadcaster for the Mexican state of Guanajuato
- Cuatro, the fourth album by thrash metal band Flotsam and Jetsam
- Cuatro (Puerto Rico), the national instrument of Puerto Rico