Ctcf

CTCF

Identifiers Symbol CTCF External IDs OMIM: 604167 MGI: 109447 HomoloGene: 4786 GeneCards: CTCF Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • transcription corepressor activity • protein binding • zinc ion binding • chromatin insulator sequence binding • sequence-specific DNA binding • transcription regulatory region DNA binding • metal ion binding
Cellular component	• chromosome, centromeric region • condensed chromosome • nucleus • nucleoplasm • nucleolus
Biological process	• regulation of gene expression by genetic imprinting • transcription, DNA-dependent • chromosome segregation • maintenance of DNA methylation • positive regulation of gene expression • chromatin modification • nucleosome positioning • regulation of histone methylation • regulation of histone acetylation • regulation of gene expression, epigenetic • regulation of molecular function, epigenetic • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • regulation of centromeric sister chromatid cohesion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10664 13018 Ensembl ENSG00000102974 ENSMUSG00000005698 UniProt P49711 Q61164 RefSeq (mRNA) NM_001191022.1 NM_181322.3 RefSeq (protein) NP_001177951.1 NP_851839.1 Location (UCSC) Chr 16:
67.6 – 67.67 Mb Chr 8:
105.64 – 105.68 Mb PubMed search

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity and regulation of chromatin architecture.