CPK may refer to:
- Cpk, a measure of process capability in Six Sigma
- CPK coloring, a way to color atoms when visualizing molecular models
- "C.P.K." (Crazy Poway Kids), a 1995 song by Unwritten Law from their album Blue Room
- Cabbage Patch Kids
- California Pizza Kitchen
- Carpenders Park railway station, England (National Rail station code)
- Central Park in New York City
- Chesapeake Utilities (New York Stock Exchange symbol)
- Church of the Province of Kenya, a former name for the Anglican Church of Kenya
- Communist Party of Kampuchea, commonly known as the Khmer Rouge
- Composite primary key, a primary key comprising more than one field
- Creatine phosphokinase, an enzyme found in humans, or alternatively a blood test for it.