Coxsackie B4 virus is a virus which can trigger an autoimmune reaction which results in destruction of the insulin-producing beta cells of the pancreas, which is one of several different etiologies of diabetes mellitus.
An absolute deficiency of insulin renders the person a type 1 diabetic. There are several viruses in the Coxsackie family and many of them seem to evoke this response, as do several other agents. A genetic predisposition appears to be important, such that individuals with human leukocyte antigen types DR3 and DR4 predominate in the affected population.
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“Think of the earth as a living organism that is being attacked by billions of bacteria whose numbers double every forty years. Either the host dies, or the virus dies, or both die.”
—Gore Vidal (b. 1925)